I-TASSER results

I-TASSER results for job id Rv0026

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (448 residues)
MAFDAAMSTHEDLLATIRYVRDRTGDPNAWQTGLTPTEVTAVVTSTTRSEQLDAILRKIR
QRHSNLYYPAPPDREQGDAARAIADAEAALAHQNSATAQLDLQVVSAILNAHLKTVEGGE
SLHELQQEIEAAVRIRSDLDTPAGARDFQRFLIGKLKDIREVVATASLDAASKSALMAAW
TSLYDASKGDRGDADDRGPASVGSGGAPARGAGQQPELPTRAEPDCLLDSLLLEDPGLLA
DDLQVPGGTSAAIPSASSTPSLPNLGGATMPGGGATPALVPGVSAPGGLPLSGLLRGVGD
EPELTDFDERGQEVRDPADYEHSNEPDERRADDREGADEDAGLGKSESPPQAPTTVTLPN
GETVTAASPQLAAAIKAAASGTPIADAFQQQGIAIPLPGTAVANPVDPARISAGDVGVFT
ATPLPLALAKLFWTARFNTSQPCEGQTF

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAFDAAMSTHEDLLATIRYVRDRTGDPNAWQTGLTPTEVTAVVTSTTRSEQLDAILRKIRQRHSNLYYPAPPDREQGDAARAIADAEAALAHQNSATAQLDLQVVSAILNAHLKTVEGGESLHELQQEIEAAVRIRSDLDTPAGARDFQRFLIGKLKDIREVVATASLDAASKSALMAAWTSLYDASKGDRGDADDRGPASVGSGGAPARGAGQQPELPTRAEPDCLLDSLLLEDPGLLADDLQVPGGTSAAIPSASSTPSLPNLGGATMPGGGATPALVPGVSAPGGLPLSGLLRGVGDEPELTDFDERGQEVRDPADYEHSNEPDERRADDREGADEDAGLGKSESPPQAPTTVTLPNGETVTAASPQLAAAIKAAASGTPIADAFQQQGIAIPLPGTAVANPVDPARISAGDVGVFTATPLPLALAKLFWTARFNTSQPCEGQTF
Prediction	CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHCCCCCCHHHHHHHHHCCCCCHCHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCCCCCCCCCCC
Conf.Score	9876555678999999986567888987667788888776545888886776666654675444446789998888876655667677766567776555556677776655566778888878888888764678888986555677888765655455546788888777776677888889999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999898888999999999999999999999999999999999999999888888888888886465676556667888999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAFDAAMSTHEDLLATIRYVRDRTGDPNAWQTGLTPTEVTAVVTSTTRSEQLDAILRKIRQRHSNLYYPAPPDREQGDAARAIADAEAALAHQNSATAQLDLQVVSAILNAHLKTVEGGESLHELQQEIEAAVRIRSDLDTPAGARDFQRFLIGKLKDIREVVATASLDAASKSALMAAWTSLYDASKGDRGDADDRGPASVGSGGAPARGAGQQPELPTRAEPDCLLDSLLLEDPGLLADDLQVPGGTSAAIPSASSTPSLPNLGGATMPGGGATPALVPGVSAPGGLPLSGLLRGVGDEPELTDFDERGQEVRDPADYEHSNEPDERRADDREGADEDAGLGKSESPPQAPTTVTLPNGETVTAASPQLAAAIKAAASGTPIADAFQQQGIAIPLPGTAVANPVDPARISAGDVGVFTATPLPLALAKLFWTARFNTSQPCEGQTF
Prediction	6314301321430030044035344434223341444412212334344522540354044425523431245743143252145155414544432441344035104413431350254055035404523544541433302430351045324303521652444453445235424542634556544454444544545442554454625454445442234532445323447524444444444244444342263444443444434444243644452435434544466254544666355254166554465454554545555466453564643465444252174644625525335335433535326442556636424564336623516424214123133320101301000102033145174574
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHCCCCCCHHHHHHHHHCCCCCHCHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCCCCCCCCCCC
MAFDAAMSTHEDLLATIRYVRDRTGDPNAWQTGLTPTEVTAVVTSTTRSEQLDAILRKIRQRHSNLYYPAPPDREQGDAARAIADAEAALAHQNSATAQLDLQVVSAILNAHLKTVEGGESLHELQQEIEAAVRIRSDLDTPAGARDFQRFLIGKLKDIREVVATASLDAASKSALMAAWTSLYDASKGDRGDADDRGPASVGSGGAPARGAGQQPELPTRAEPDCLLDSLLLEDPGLLADDLQVPGGTSAAIPSASSTPSLPNLGGATMPGGGATPALVPGVSAPGGLPLSGLLRGVGDEPELTDFDERGQEVRDPADYEHSNEPDERRADDREGADEDAGLGKSESPPQAPTTVTLPNGETVTAASPQLAAAIKAAASGTPIADAFQQQGIAIPLPGTAVANPVDPARISAGDVGVFTATPLPLALAKLFWTARFNTSQPCEGQTF

5gaoE

0.14

0.11

0.75

1.43

MUSTER

------------------------------------------------------------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK-

5fmwA

0.07

0.99

1.34

MUSTER

SHIDCRMSPWSE------DPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCECGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGYGINILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWNVASLIYETKGEKNFRTEHYEEQIEAFKSIIQEKTSNFNAAISLKFTPGKGSFRFSYSKNETYQLFLSYSSKKEKMFLHVKGEIHLGRFVMRNRDVVLTTTFVDDIKALPTTYEKGEYFAFLETYGSSGSLGGLYELIYVLDKASMKRKGVELKDIKRCLGYHLDVSLAFSEISVGAEFNKDDCVKRGEGRAVNITSENLIDDVVSLIRGGTRKYAFELKEKLLRGTVIDVTDFVNWASSINDAPVLKLSPIYNLVPVKMKNAHLKKQNLERAIEDYINEFSVTVILMDFKF

5gaoE

0.15

0.11

0.75

1.73

dPPAS

-----------------------------------------------------------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK---------

1w0sA

0.10

0.09

0.89

1.20

wMUSTER

--------------------------LCFTQYEESSGKCKGLLGGGVSVEDCLNTAFAYQKRSGGLCQPCRSPRSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWS--------GWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPTCNHPVPQHGGPFCAGDATRTHICNTAVP--CPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLMPPCGPNPTRARQRLCTPLLPKYPPTVSMVEGQGENVTFWGRPLPRCEELQGQKLVVEEK------------RPCLHVPACKDPEE

5gaoE

0.16

0.11

0.72

1.20

wdPPAS

-------------------------------------------------------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKK------------------

1w0sA

0.09

0.96

1.34

MUSTER

-----------DPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWS--------GWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTPLLPKYPPTVSMVEGQGEKNVTFWGRP-LPRCEELQGQKLVVEEKRPCLHVPACKDPEE

5gaoE

0.16

0.12

0.75

1.37

wMUSTER

-------------------------------------------------------------------------------------AAAAAA----------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEA-LSQKFHGTKSNKK---

1w0sA

0.06

0.93

1.25

dPPAS

--------------------DPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEW-------------QLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEEL

5gaoE

0.15

0.11

0.75

2.40

wPPAS

-------------------------------------------------------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEA--SQKFHGTKSNKK---

3iymA

0.14

0.12

0.82

1.09

wdPPAS

SASKAAA-----------FAQGGSSDPVP-MPGKYPVVFSTGAGEPTRDQEF-----ALPVHKAFPLFGSVSDKYRRNPRYA-------RAHSEFTDGVFGTHLAVSSL--------------RLAQQL---VHAHVNMGLPLG-------------DFAPLASSDVRIPSALASVVNQFGEFSSPSIGTRRDFEHAVSRVVFLADQLWTNGNSHHIFARSWLPMSNNDG---NFKTIVASRLLE---SAGDLSILPTVLEDAVLSGEVPEAWEQVKDLLGDAPGVGQVDRRDLFKSYADVGQFTTAFTTQAASDVLTELGLPNSPSAGHLNWQYSTKQRFTFLADTWAKLSAASSGLATRQSATGSHAQMVDL--TSVEGVTVLKAA----LALSAPEFSLAACFPPSCIFVGGLTVVVTTSLSVSQ---------------RATEF

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.32

Estimated TM-score = 0.44±0.14

Estimated RMSD = 12.7±4.3Å

Download Model 2

C-score=-2.90

Download Model 3

C-score=-2.79

Download Model 4

C-score=-3.11

Download Model 5

C-score=-3.74

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5fmwA	0.946	1.84	0.070	0.984
2	3ojyB	0.610	3.94	0.055	0.734
3	3t5oA	0.605	4.30	0.044	0.739
4	3ojyA	0.573	4.17	0.076	0.694
5	3nsjA	0.439	4.02	0.054	0.527
6	2bk1A	0.428	5.59	0.065	0.585
7	2qqhA	0.401	3.51	0.074	0.464
8	2qp2A	0.394	4.90	0.049	0.507
9	5j67A	0.366	4.91	0.064	0.471
10	3kk7A	0.337	5.66	0.032	0.469

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.07	3	4lq3A	20V	Rep, Mult	426,427,430
2	0.05	2	1m3xL	BPH	Rep, Mult	424,427,428
3	0.02	1	1d4m1	MYR	Rep, Mult	414,415
4	0.02	1	3bbxL	MG	Rep, Mult	380,381
5	0.02	1	3nbsD	HEM	Rep, Mult	1,3,13
6	0.02	1	5sy1A	CLR	Rep, Mult	431,434
7	0.02	1	2zt9G	III	Rep, Mult	418,426
8	0.02	1	3ufkA	NTA	Rep, Mult	309,310
9	0.02	1	2xydB	UUU	Rep, Mult	365,367,400,401
10	0.02	1	1n47A	UUU	Rep, Mult	359,360
11	0.02	1	4a5tS	UUU	Rep, Mult	269,271
12	0.02	1	3pcaM	DHB	Rep, Mult	369,375
13	0.02	1	1d6nA	MG	Rep, Mult	234,235
14	0.02	1	2wocA	MN	Rep, Mult	138,140,141
15	0.02	1	3ufkA	FE	Rep, Mult	155,309
16	0.02	1	2c6nB	NDG	Rep, Mult	373,376,377,380
17	0.02	1	1s5lL	CLA	Rep, Mult	428,432
18	0.02	1	3nbsB	HEM	Rep, Mult	3,13
19	0.02	1	2a69A	MG	Rep, Mult	329,330

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3fg3A	0.263	6.91	0.029	0.413	4.2.1.92,1.13.11.40	NA
2	0.060	3b9jI	0.142	5.72	0.038	0.203	1.17.1.4,1.17.3.2	388
3	0.060	1clqA	0.247	6.78	0.048	0.386	2.7.7.7	397
4	0.060	1b0pA	0.279	6.52	0.041	0.429	1.2.7.1	NA
5	0.060	2vdcA	0.282	7.14	0.052	0.464	1.4.1.13	NA
6	0.060	1n63B	0.299	6.63	0.030	0.467	1.2.99.2	NA
7	0.060	1cf9A	0.300	6.70	0.074	0.469	1.11.1.6	NA
8	0.060	3b9jC	0.260	7.65	0.053	0.455	1.17.3.2,1.17.1.4	NA
9	0.060	2gbcA	0.277	6.97	0.019	0.446	3.4.14.5,3.4.15.5	292
10	0.060	3g4dA	0.276	7.18	0.047	0.455	4.2.3.13	NA
11	0.060	2cseW	0.306	7.55	0.047	0.529	3.6.4.13	NA
12	0.060	3b9jJ	0.198	6.72	0.037	0.312	1.17.1.4,1.17.3.2	120,131,256,283
13	0.060	1n1hA	0.278	7.14	0.043	0.462	2.7.7.48	259
14	0.060	2e1qA	0.265	7.12	0.047	0.431	1.17.3.2,1.17.1.4	NA
15	0.060	2w00B	0.290	7.25	0.061	0.484	3.1.21.3	432
16	0.060	1u22A	0.275	7.27	0.037	0.458	2.1.1.14	NA
17	0.060	2iw5A	0.294	7.35	0.047	0.491	1.-.-.-	NA
18	0.060	3g0bB	0.276	7.08	0.031	0.449	3.4.14.5	199
19	0.060	2gmhA	0.294	7.04	0.051	0.482	1.5.5.1	403,404

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.24	0.946	1.84	0.07	0.98	5fmwA	GO:0002376 GO:0005576 GO:0005579 GO:0005737 GO:0005886 GO:0005887 GO:0006955 GO:0006957 GO:0006958 GO:0016020 GO:0016021 GO:0019835 GO:0019836 GO:0030449 GO:0045087 GO:0070062 GO:0072562
1	0.07	0.610	3.94	0.06	0.73	3ojyB	GO:0002376 GO:0005576 GO:0005579 GO:0005615 GO:0006955 GO:0006956 GO:0006957 GO:0006958 GO:0016020 GO:0019835 GO:0030449 GO:0032403 GO:0045087 GO:0070062 GO:1903561
2	0.07	0.598	4.36	0.05	0.73	4e0sB	GO:0001701 GO:0001970 GO:0002376 GO:0005576 GO:0005579 GO:0006955 GO:0006956 GO:0006958 GO:0019835 GO:0030449 GO:0045087 GO:0045766 GO:0045917 GO:0070062
3	0.07	0.605	4.30	0.04	0.74	3t5oA	GO:0001701 GO:0001970 GO:0002376 GO:0005576 GO:0005579 GO:0006955 GO:0006956 GO:0006958 GO:0019835 GO:0030449 GO:0045087 GO:0045766 GO:0045917 GO:0070062
4	0.07	0.573	4.17	0.08	0.69	3ojyA	GO:0001848 GO:0002376 GO:0005576 GO:0005579 GO:0005615 GO:0005886 GO:0006955 GO:0006956 GO:0006957 GO:0006958 GO:0016020 GO:0016021 GO:0019835 GO:0030449 GO:0032403 GO:0045087 GO:0070062 GO:0072562
5	0.07	0.566	4.29	0.05	0.69	4a5wB	GO:0001701 GO:0001970 GO:0002376 GO:0005576 GO:0005579 GO:0006955 GO:0006956 GO:0006958 GO:0019835 GO:0030449 GO:0045087 GO:0045766 GO:0045917 GO:0070062
6	0.06	0.439	4.02	0.05	0.53	3nsjA	GO:0001771 GO:0002357 GO:0002418 GO:0005509 GO:0005576 GO:0005768 GO:0005886 GO:0016020 GO:0016021 GO:0016023 GO:0019835 GO:0022829 GO:0031904 GO:0044194 GO:0046872 GO:0051260 GO:0051607 GO:0055085
7	0.06	0.394	4.90	0.05	0.51	2qp2A	GO:0046872
8	0.06	0.401	3.51	0.07	0.46	2qqhA	GO:0001848 GO:0002376 GO:0005576 GO:0005579 GO:0005615 GO:0005886 GO:0006955 GO:0006956 GO:0006957 GO:0006958 GO:0016020 GO:0016021 GO:0019835 GO:0030449 GO:0032403 GO:0045087 GO:0070062 GO:0072562
9	0.06	0.384	3.80	0.06	0.46	2rd7A	GO:0001848 GO:0002376 GO:0005576 GO:0005579 GO:0005615 GO:0005886 GO:0006955 GO:0006956 GO:0006957 GO:0006958 GO:0016020 GO:0016021 GO:0019835 GO:0030449 GO:0032403 GO:0045087 GO:0070062 GO:0072562
10	0.06	0.368	4.85	0.06	0.47	5j67C	GO:0005509 GO:0005768 GO:0016020 GO:0016021 GO:0043533 GO:0060187 GO:2000009
11	0.06	0.219	7.90	0.03	0.39	2xrcB	GO:0002376 GO:0004252 GO:0005044 GO:0005576 GO:0005615 GO:0006508 GO:0006898 GO:0006958 GO:0008233 GO:0008236 GO:0016020 GO:0016787 GO:0030449 GO:0045087 GO:0046872 GO:0070062
12	0.06	0.217	7.80	0.02	0.38	2xrcC	GO:0002376 GO:0004252 GO:0005044 GO:0005576 GO:0005615 GO:0006508 GO:0006898 GO:0006958 GO:0008233 GO:0008236 GO:0016020 GO:0016787 GO:0030449 GO:0045087 GO:0046872 GO:0070062
13	0.06	0.209	7.90	0.03	0.38	3ki9A	GO:0006508 GO:0008152 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0016805 GO:0046872
14	0.06	0.205	6.42	0.06	0.31	3vywD	GO:0016645 GO:0046872 GO:0051536 GO:0051539 GO:0055114
15	0.06	0.200	7.40	0.01	0.34	1n7dA	GO:0001618 GO:0001948 GO:0002020 GO:0004872 GO:0005041 GO:0005509 GO:0005764 GO:0005768 GO:0005769 GO:0005770 GO:0005794 GO:0005886 GO:0005887 GO:0005905 GO:0006629 GO:0006810 GO:0006869 GO:0006897 GO:0006898 GO:0008202 GO:0008203 GO:0009897 GO:0009986 GO:0010008 GO:0010867 GO:0010899 GO:0012505 GO:0015914 GO:0016020 GO:0016021 GO:0016032 GO:0016323 GO:0030169 GO:0030229 GO:0030299 GO:0030301 GO:0030669 GO:0032050 GO:0034362 GO:0034383 GO:0042157 GO:0042159 GO:0042632 GO:0042802 GO:0043235 GO:0045177 GO:0046718 GO:0070508 GO:1990666 GO:2000188
16	0.06	0.197	5.84	0.03	0.28	5fttA	GO:0005886 GO:0006915 GO:0007165 GO:0007275 GO:0007411 GO:0009986 GO:0016020 GO:0016021 GO:0021859 GO:0098609 GO:2001222
17	0.06	0.196	5.78	0.06	0.28	4v2aA	GO:0005886 GO:0006915 GO:0007165 GO:0007275 GO:0007411 GO:0016020 GO:0016021 GO:0031175 GO:0031226 GO:0032589 GO:0032809 GO:0033564 GO:0038007 GO:0042995 GO:0045121
18	0.06	0.174	7.45	0.03	0.30	3vn4A	GO:0004175 GO:0004222 GO:0005178 GO:0005509 GO:0005576 GO:0005578 GO:0005615 GO:0005788 GO:0006508 GO:0007160 GO:0007229 GO:0007596 GO:0007599 GO:0008233 GO:0008237 GO:0008270 GO:0009100 GO:0009636 GO:0009986 GO:0016485 GO:0016787 GO:0030168 GO:0034341 GO:0034612 GO:0036066 GO:0043171 GO:0046872 GO:0070670

Consensus prediction of GO terms

Molecular Function	GO:0032403	GO:0001848
GO-Score	0.13	0.07
Biological Processes	GO:0052331	GO:0001897	GO:0030449	GO:0006958	GO:0006957
GO-Score	0.48	0.48	0.42	0.42	0.34
Cellular Component	GO:0005615	GO:0044424	GO:0070062	GO:0005579
GO-Score	0.58	0.48	0.42	0.42

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.