I-TASSER results

I-TASSER results for job id Rv0021c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (322 residues)
MVLSTAFSQMFGIDYPIVSAPMDLIAGGELAAAVSGAGGLGLIGGGYGDRDWLARQFDLA
AGAPVGCGFITWSLARQPQLLDLALQYEPVAVMLSFGDPAVFADAIKSAGTRLVCQIQNR
TQAERALQVGADVLVAQGTEAGGHGHGPRSTLTLVPEIVDLVTARGTDIPVIAAGGIADG
RGLAAALMLGAAGVLVGTRFYATVEALSTPQARDPLLAATGDDMCRTTIYDQLRRYPWPQ
GHTMSVLSNALTDQFEDTELDILHREEAMARYWRAVAARDYSIANVTAGQAAGLVNAVLP
AADVITGMAQQAARTLTAMRAV

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVLSTAFSQMFGIDYPIVSAPMDLIAGGELAAAVSGAGGLGLIGGGYGDRDWLARQFDLAAGAPVGCGFITWSLARQPQLLDLALQYEPVAVMLSFGDPAVFADAIKSAGTRLVCQIQNRTQAERALQVGADVLVAQGTEAGGHGHGPRSTLTLVPEIVDLVTARGTDIPVIAAGGIADGRGLAAALMLGAAGVLVGTRFYATVEALSTPQARDPLLAATGDDMCRTTIYDQLRRYPWPQGHTMSVLSNALTDQFEDTELDILHREEAMARYWRAVAARDYSIANVTAGQAAGLVNAVLPAADVITGMAQQAARTLTAMRAV
Prediction	CCCCCHHHHHHCCCCCEEHCCCCCCCCHHHHHHHHHCCCCCHCCCCCCCHHHHHHHHHHHCCCCEEEEEHCCCCCCHHHHHHHHHHHCCCEEEHCCCCHHHHHHHHHHHCCEEEEHCCCHHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEHCCCCCHHHHHHHHHHCCCEEEHCHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEEHCCCCCCCCCCCCCEEEHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHC
Conf.Score	9998888999899986786687756798999999986975555899999999999999976999588887699986899999999989999998699959999999998998999759999999999989999999678888899988874489999999999758898599978888999999999989986886445654787789999999999899986899755445666677788856775788999999865557775778888999999899765645444678766778899999999999999999999869
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVLSTAFSQMFGIDYPIVSAPMDLIAGGELAAAVSGAGGLGLIGGGYGDRDWLARQFDLAAGAPVGCGFITWSLARQPQLLDLALQYEPVAVMLSFGDPAVFADAIKSAGTRLVCQIQNRTQAERALQVGADVLVAQGTEAGGHGHGPRSTLTLVPEIVDLVTARGTDIPVIAAGGIADGRGLAAALMLGAAGVLVGTRFYATVEALSTPQARDPLLAATGDDMCRTTIYDQLRRYPWPQGHTMSVLSNALTDQFEDTELDILHREEAMARYWRAVAARDYSIANVTAGQAAGLVNAVLPAADVITGMAQQAARTLTAMRAV
Prediction	4626030052060410000000000031400000040100000002423152025105604721000000002243143003000615030000001214500520272402000001116103301712000000001101113435212010032004103647160000000001104100100000000000000000042061275015202615552101020123244343332110000214006414726563153541243134004533252020000100210451520540053016103500530577
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCHHHHHHCCCCCEEHCCCCCCCCHHHHHHHHHCCCCCHCCCCCCCHHHHHHHHHHHCCCCEEEEEHCCCCCCHHHHHHHHHHHCCCEEEHCCCCHHHHHHHHHHHCCEEEEHCCCHHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEHCCCCCHHHHHHHHHHCCCEEEHCHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEEHCCCCCCCCCCCCCEEEHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHC
MVLSTAFSQMFGIDYPIVSAPMDLIAGGELAAAVSGAGGLGLIGGGYGDRDWLARQFDLAAGAPVGCGFITWSLARQPQLLDLALQYEPVAVMLSFGDPAVFADAIKSAGTRLVCQIQNRTQAERALQVGADVLVAQGTEAGGHGHGPRSTLTLVPEIVDLVTARGTDIPVIAAGGIADGRGLAAALMLGAAGVLVGTRFYATVEALSTPQARDPLLAATGDDMCRTTIYDQLRRYPWPQGHTMSVLSNALTDQFEDTELDILHREEAMARYWRAVAARDYSIANVTAGQAAGLVNAVLPAADVITGMAQQAARTLTAMRAV

4iqlA

0.30

0.28

0.93

3.10

MUSTER

M---NRICELLGIEHPIISGGMVWCSGWKLASAVSN-GGLGLIGAGSMHPDNLEHHIRSC-DKPFGVNVPLL-YPEMDKIMEIIMREHVPVVVTSAGSPKVWTAKLKAAGSKVIHVVSSATFARKSEAAGVDAIVAEGFEAGGHNGEETTTLCLIPEVVDAV-----NIPVVAAGGIASGRAVAAALALGADAVQVGTRFALSEESSAHEDFKAHCRRSVEGDTMLSL----------KAVSPTRLLKNKFYQDVFAAEQRGASELLGRGRAKQGIFEGDLHEGELEIGQAVSQISHAETVAEIMVDLVDGYKRSLAGMPTE

4iqlA

0.29

0.28

0.94

5.82

dPPAS

---MNRICELLGIEHPIISGGMVWCSGWKLASAVSNGG-LGLIGAGSMHPDNLEHHIRSCKDKPFGVNVPLL-YPEMDKIMEIIMREHVPVVVTSAGSPKVWTAKLKAAGSKVIHVVSSATFARKSEAAGVDAIVAEGFEAGGHNGEETTTLCLIPEVVDAV-----NIPVVAAGGIASGRAVAAALALGADAVQVGTRFALSEESSAHEDFKAHCRRSVEGDTMLSL----------KAVSPTRLLKNKFYQDVFAAEQRGASELLGRGRAKQGIFEGDLHEGELEIGQAVSQISHAETVAEIMVDLVDGYKRSLAGMPTE

4iqlA

0.28

0.26

0.93

4.82

wdPPAS

M---NRICELLGIEHPIISGGMVWCSGWKLASAVSNGGLGLIG-AGSMHPDNLEHHIRSC-DKPFGVNVPLL-YPEMDKIMEIIMREHVPVVVTSAGSPKVWTAKLKAAGSKVIHVVSSATFARKSEAAGVDAIVAEGFEAGGHNGEETTTLCLIPEVVDAV-----NIPVVAAGGIASGRAVAAALALGADAVQVGTRFALSEESSAHEDFKAHCRRSVEGDTMLSL----------KAVSPTRLLKNKFYQDVFAAEQRGASELLGRGRAKQGIFEGDLHEGELEIGQAVSQISHAETVAEIMVDLVDGYKRSLAGMPTE

4iqlA

0.29

0.27

0.93

3.50

wMUSTER

----NRICELLGIEHPIISGGMVWCSGWKLASAVSNGGL-GLIGAGSMHPDNLEHHIRSC-DKPFGVNVPLL-YPEMDKIMEIIMREHVPVVVTSAGSPKVWTAKLKAAGSKVIHVVSSATFARKSEAAGVDAIVAEGFEAGGHNGEETTTLCLIPEVVDAV-----NIPVVAAGGIASGRAVAAALALGADAVQVGTRFALSEESSAHEDFKAHCRRSVEGDTMLSL----------KAVSPTRLLKNKFYQDVFAAEQRGASELLGRGRAKQGIFEGDLHEGELEIGQAVSQISHAETVAEIMVDLVDGYKRSLAGMPTE

4iqlA

0.28

0.26

0.93

4.32

wPPAS

M---NRICELLGIEHPIISGGMVWCSGWKLASAVSNGGLGLIG-AGSMHPDNLEHHIRSC-DKPFGVNVPLL-YPEMDKIMEIIMREHVPVVVTSAGSPKVWTAKLKAAGSKVIHVVSSATFARKSEAAGVDAIVAEGFEAGGHNGEETTTLCLIPEVVDAV-----NIPVVAAGGIASGRAVAAALALGADAVQVGTRFALSEESSAHEDFKAHCRRSVEGDTMLSL----------KAVSPTRLLKNKFYQDVFAAEQRGASELLGRGRAKQGIFEGDLHEGELEIGQAVSQISHAETVAEIMVDLVDGYKRSLAGMPTE

4iqlA

0.30

0.28

0.94

8.06

dPPAS2

M---NRICELLGIEHPIISGGMVWCSGWKLASAVSNGG-LGLIGAGSMHPDNLEHHIRSCKDKPFGVNVPLL-YPEMDKIMEIIMREHVPVVVTSAGSPKVWTAKLKAAGSKVIHVVSSATFARKSEAAGVDAIVAEGFEAGGHNGEETTTLCLIPEVVDAV-----NIPVVAAGGIASGRAVAAALALGADAVQVGTRFALSEESSAHEDFKAHCRRSVEGDTMLSL----------KAVSPTRLLKNKFYQDVFAAEQRGASELLGRGRAKQGIFEGDLHEGELEIGQAVSQISHAETVAEIMVDLVDGYKRSLAGMPTE

4iqlA

0.30

0.28

0.93

4.17

PPAS

M---NRICELLGIEHPIISGGMVWCSGWKLASAVSNGG-LGLIGAGSMHPDNLEHHIRSC-DKPFGVNVPLL-YPEMDKIMEIIMREHVPVVVTSAGSPKVWTAKLKAAGSKVIHVVSSATFARKSEAAGVDAIVAEGFEAGGHNGEETTTLCLIPEVVDAV-----NIPVVAAGGIASGRAVAAALALGADAVQVGTRFALSEESSAHEDFKAHCRRSVEGDTMLSL----------KAVSPTRLLKNKFYQDVFAAEQRGASELLGRGRAKQGIFEGDLHEGELEIGQAVSQISHAETVAEIMVDLVDGYKRSLAGMPTE

4iqlA

0.30

0.28

0.94

6.40

Env-PPAS

M---NRICELLGIEHPIISGGMVWCSGWKLASAVSNGG-LGLIGAGSMHPDNLEHHIRSCKDKPFGVNVPLL-YPEMDKIMEIIMREHVPVVVTSAGSPKVWTAKLKAAGSKVIHVVSSATFARKSEAAGVDAIVAEGFEAGGHNGEETTTLCLIPEVVDAV-----NIPVVAAGGIASGRAVAAALALGADAVQVGTRFALSEESSAHEDFKAHCRRSVEGDTMLSL----------KAVSPTRLLKNKFYQDVFAAEQRGASELLGRGRAKQGIFEGDLHEGELEIGQAVSQISHAETVAEIMVDLVDGYKRSLAGMPTE

2gjlA

0.25

0.24

0.95

3.02

MUSTER

V-FRTRFTETFGVEHPIMQGGMQWVGRAEMAAAVANAGGLATLSALTQSPEALAAEIARCRDRPFGVNLTLLPTVPYAEYRAAIIEAGIRVVETAGNDPGEHIAEFRRHGVKVIHKCTAVRHALKAERLGVDAVSIDGFECAGHPGDDIPGLVLLPAAANRL-----RVPIIASGGFADGRGLVAALALGADAINMGTRFLATRECPIHPAVKAAIRAADERSTDLIMRSL---------RNTARVARNAISQEVLAIEARGAGYADSGQRGRQVYQQGDTDLGIWSAGMVQGLIDDEPACAELLRDIVEQARQLVRQRLEG

2gjlA

0.25

0.24

0.95

5.65

dPPAS

-VFRTRFTETFGVEHPIMQGGMQWVGRAEMAAAVANAGGLATLSALTQSPEALAAEIARCRDRPFGVNLTLLKPVPYAEYRAAIIEAGIRVVETAGNDPGEHIAEFRRHGVKVIHKCTAVRHALKAERLGVDAVSIDGFECAGHPGDDIPGLVLLPAAANRL-----RVPIIASGGFADGRGLVAALALGADAINMGTRFLATRECPIHPAVKAAIRAADERSTDLIMRSL---------RNTARVARNAISQEVLAIEARGGAGYADGQRGRQVYQQGDTDLGIWSAGMVQGLIDDEPACAELLRDIVEQARQLVRQRLEG

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 1 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.28

Estimated TM-score = 0.89±0.07

Estimated RMSD = 3.7±2.5Å

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4iqlA	0.912	1.19	0.298	0.938
2	2gjlA	0.910	1.49	0.248	0.953
3	4z9rA	0.886	2.32	0.210	0.975
4	4z38A	0.884	2.22	0.174	0.966
5	2z6iB	0.879	1.41	0.336	0.916
6	3bo9A	0.878	1.55	0.316	0.922
7	3hmjG	0.851	2.64	0.158	0.960
8	2uvcG	0.850	2.66	0.155	0.960
9	3bw3A	0.834	2.48	0.285	0.910
10	4q4kA	0.826	2.49	0.306	0.907

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.87	73	2uv8G	FMN	Rep, Mult	20,21,22,23,24,68,70,95,116,137,141,142,175,176,197,198,201,287
2	0.04	4	2z6jB	TUI	Rep, Mult	23,70,72,96,97,116,118,122,137,143,144
3	0.03	3	4qitA	NIE	Rep, Mult	70,143,144,288
4	0.02	2	2z6iA	CA	Rep, Mult	159,162,168
5	0.01	2	4iqlA	NDP	Rep, Mult	24,25,26,27,28,29,47,48,52,55,56,207,277
6	0.01	1	1b3oA	SAE	Rep, Mult	118,119,137,154,175,197
7	0.01	1	3bw3A	NIE	Rep, Mult	23,24,47,265,272,287
8	0.01	1	2z6iA	CA	Rep, Mult	137,144
9	0.01	1	4iqlA	NDP	Rep, Mult	24,46,47,48,49,74,75,76,269,270,273

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.241	2czfA	0.485	3.35	0.143	0.584	4.1.1.23	23
2	0.211	1xi3B	0.528	2.56	0.156	0.593	2.5.1.3	175
3	0.203	1xi3A	0.530	2.65	0.176	0.599	2.5.1.3	NA
4	0.164	2c0aB	0.519	3.23	0.112	0.612	4.1.2.14,4.1.3.16	97,176
5	0.120	2v81A	0.535	2.79	0.168	0.612	4.1.2.21	NA
6	0.105	1mxsA	0.518	3.40	0.097	0.621	4.1.2.14	NA
7	0.104	1vlwB	0.526	2.97	0.141	0.609	4.1.3.16	NA
8	0.103	1v5xA	0.490	3.24	0.143	0.581	5.3.1.24	NA
9	0.099	2yw3E	0.503	3.15	0.124	0.593	4.1.2.14	NA
10	0.097	1nsjA	0.494	3.30	0.131	0.587	5.3.1.24	NA
11	0.094	1wbhB	0.519	3.23	0.112	0.612	4.1.3.16,4.1.2.14	NA
12	0.073	1g69B	0.535	3.07	0.150	0.624	2.5.1.3	NA
13	0.072	1xbzB	0.507	3.62	0.118	0.627	4.1.1.85	NA
14	0.070	1w0mA	0.529	3.03	0.203	0.606	5.3.1.1	143
15	0.067	2fliC	0.507	3.40	0.129	0.618	5.1.3.1	NA
16	0.067	1hg3A	0.529	2.67	0.146	0.593	5.3.1.1	142
17	0.067	3f4wA	0.503	3.40	0.153	0.603	4.1.2.-	20,175,203
18	0.067	2cz5A	0.487	3.42	0.143	0.587	4.1.1.23	NA
19	0.067	2h6rB	0.500	2.92	0.162	0.571	5.3.1.1	NA
20	0.060	2uv8G	0.853	2.60	0.158	0.960	2.3.1.86	NA
21	0.060	1llwA	0.609	3.45	0.140	0.717	1.4.7.1	NA
22	0.060	2c6qG	0.665	3.67	0.146	0.804	1.7.1.7	175
23	0.060	2cu0A	0.676	3.29	0.153	0.786	1.1.1.205	175,177
24	0.060	2z6iB	0.879	1.41	0.336	0.916	1.3.1.9	44,141,143,151,175,177,197,288,290
25	0.060	2rduA	0.602	3.00	0.166	0.689	1.1.3.15	NA
26	0.060	1vrdA	0.666	3.20	0.210	0.767	1.1.1.205	23,175
27	0.060	1kbiA	0.601	3.26	0.153	0.708	1.1.2.3	NA
28	0.060	2vdcA	0.608	3.48	0.154	0.717	1.4.1.13	NA
29	0.060	1nvmA	0.573	4.15	0.096	0.736	4.1.3.38	NA
30	0.060	1eepB	0.654	3.35	0.171	0.758	1.1.1.205	95,175,197
31	0.060	3bw4A	0.839	2.58	0.290	0.919	1.7.3.1	20,22,137,141,143,174,177,191,197
32	0.060	1p4cA	0.569	3.33	0.162	0.671	1.1.99.31	NA
33	0.060	2qf7B	0.583	4.64	0.090	0.779	6.4.1.1	NA
34	0.060	1ofdA	0.607	3.47	0.145	0.717	1.4.7.1	NA
35	0.060	1zfjA	0.663	3.43	0.171	0.773	1.1.1.205	NA
36	0.060	1jcnB	0.642	2.43	0.218	0.711	1.1.1.205	22,175,177
37	0.060	2gjlA	0.910	1.49	0.248	0.953	1.13.12.16	143,197
38	0.060	1nf7A	0.686	3.27	0.218	0.795	1.1.1.205	88

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.49	0.906	1.50	0.31	0.95	3bo9A	GO:0003824 GO:0004318 GO:0016491 GO:0018580 GO:0055114
1	0.45	0.912	1.19	0.30	0.94	4iqlA	GO:0000166 GO:0003824 GO:0018580 GO:0055114
2	0.44	0.905	1.41	0.33	0.94	2z6iB	GO:0000166 GO:0003824 GO:0004318 GO:0016491 GO:0018580 GO:0051213 GO:0055114
3	0.43	0.839	2.56	0.29	0.92	3bw2A	GO:0000166 GO:0003824 GO:0018580 GO:0051213 GO:0055114
4	0.39	0.826	2.49	0.31	0.91	4q4kA	GO:0000166 GO:0003824 GO:0018580 GO:0055114
5	0.38	0.910	1.49	0.25	0.95	2gjlA	GO:0003824 GO:0004497 GO:0016491 GO:0018580 GO:0055114
6	0.32	0.687	3.24	0.21	0.80	1jr1B	GO:0000166 GO:0003824 GO:0003938 GO:0005634 GO:0005737 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
7	0.28	0.685	3.51	0.17	0.80	1zfjA	GO:0000166 GO:0003824 GO:0003938 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
8	0.26	0.683	3.69	0.19	0.81	4myxG	GO:0000166 GO:0003824 GO:0003938 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
9	0.25	0.517	2.98	0.13	0.60	2wjzE	GO:0000105 GO:0000107 GO:0003824 GO:0005622 GO:0005737 GO:0008152 GO:0008652 GO:0016829
10	0.24	0.687	3.52	0.18	0.81	1me7A	GO:0000166 GO:0003824 GO:0003938 GO:0005737 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
11	0.22	0.681	3.27	0.18	0.79	5ahmA	GO:0000166 GO:0003824 GO:0003938 GO:0005524 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
12	0.20	0.666	3.20	0.21	0.77	1vrdA	GO:0000166 GO:0003824 GO:0003938 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
13	0.20	0.676	3.48	0.15	0.80	4qj1D	GO:0003824 GO:0003938 GO:0005737 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
14	0.11	0.703	3.75	0.18	0.84	4af0A	GO:0000166 GO:0003824 GO:0003938 GO:0005737 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
15	0.11	0.513	3.76	0.14	0.63	3w9zA	GO:0000049 GO:0002943 GO:0003723 GO:0003824 GO:0005829 GO:0008033 GO:0010181 GO:0016491 GO:0017150 GO:0050660 GO:0055114
16	0.11	0.684	3.67	0.16	0.81	4fxsA	GO:0000166 GO:0003824 GO:0003938 GO:0006164 GO:0006177 GO:0009152 GO:0016491 GO:0046872 GO:0055114
17	0.11	0.682	3.41	0.17	0.80	4fo4A	GO:0000166 GO:0003824 GO:0003938 GO:0006164 GO:0006177 GO:0009152 GO:0016491 GO:0046872 GO:0055114
18	0.11	0.684	3.63	0.19	0.81	3tsbB	GO:0000166 GO:0003824 GO:0003938 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
19	0.10	0.689	3.30	0.16	0.80	4zqrC	GO:0000166 GO:0003824 GO:0003938 GO:0005618 GO:0005886 GO:0006164 GO:0006177 GO:0006204 GO:0016491 GO:0040007 GO:0046872 GO:0055114 GO:0097293
20	0.10	0.699	3.24	0.18	0.81	4z0gB	GO:0000166 GO:0003824 GO:0003938 GO:0005737 GO:0005829 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
21	0.10	0.676	3.29	0.15	0.79	2cu0A	GO:0000166 GO:0003824 GO:0003938 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
22	0.10	0.686	3.69	0.18	0.81	3tsbA	GO:0000166 GO:0003824 GO:0003938 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
23	0.07	0.516	3.10	0.17	0.60	1h5yB	GO:0000105 GO:0000107 GO:0003824 GO:0005622 GO:0005737 GO:0008152 GO:0008652 GO:0016829
24	0.07	0.501	3.35	0.17	0.60	4x2rA	GO:0000105 GO:0000162 GO:0003824 GO:0003949 GO:0004640 GO:0005737 GO:0008152 GO:0008652 GO:0016853

Consensus prediction of GO terms

Molecular Function	GO:0018580	GO:0000166	GO:0004318	GO:0051213
GO-Score	0.95	0.89	0.71	0.68
Biological Processes	GO:0055114
GO-Score	0.95
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.